Via Lukas Mathis:
R. Clayton Miller's 10/GUI is probably one of the most dramatic reimaginations of the desktop user interface I've seen in a long time. This concept proposes a multitouch interaction system that does not require a multitouch screen (and thus does not have to deal with all the problems such a screen causes), but instead uses a multitouch area near the keyboard. The proposed graphical user interface makes full use of this multitouch area.